diff --git a/cmake/python.cmake b/cmake/python.cmake
index 9922407aa7..9efe5230c9 100644
--- a/cmake/python.cmake
+++ b/cmake/python.cmake
@@ -219,25 +219,7 @@ endif()
 #######################
 ##  PYTHON WRAPPERS  ##
 #######################
-# CMake will remove all '-D' prefix (i.e. -DUSE_FOO become USE_FOO)
-#get_target_property(FLAGS ${PROJECT_NAMESPACE}::ortools COMPILE_DEFINITIONS)
-set(FLAGS -DUSE_BOP -DUSE_GLOP -DABSL_MUST_USE_RESULT)
-if(USE_COINOR)
-  list(APPEND FLAGS "-DUSE_CBC" "-DUSE_CLP")
-endif()
-if(USE_GLPK)
-  list(APPEND FLAGS "-DUSE_GLPK")
-endif()
-if(USE_HIGHS)
-  list(APPEND FLAGS "-DUSE_HIGHS")
-endif()
-if(USE_PDLP)
-  list(APPEND FLAGS "-DUSE_PDLP")
-endif()
-if(USE_SCIP)
-  list(APPEND FLAGS "-DUSE_SCIP")
-endif()
-list(APPEND CMAKE_SWIG_FLAGS ${FLAGS} "-I${PROJECT_SOURCE_DIR}")
+list(APPEND CMAKE_SWIG_FLAGS "-I${PROJECT_SOURCE_DIR}")
 
 set(PYTHON_PROJECT ${PROJECT_NAME})
 message(STATUS "Python project: ${PYTHON_PROJECT}")
diff --git a/ortools/algorithms/python/CMakeLists.txt b/ortools/algorithms/python/CMakeLists.txt
index 9748d0b53e..bd10034b43 100644
--- a/ortools/algorithms/python/CMakeLists.txt
+++ b/ortools/algorithms/python/CMakeLists.txt
@@ -14,7 +14,7 @@
 set_property(SOURCE knapsack_solver.i PROPERTY CPLUSPLUS ON)
 set_property(SOURCE knapsack_solver.i PROPERTY SWIG_MODULE_NAME pywrapknapsack_solver)
 set_property(SOURCE knapsack_solver.i PROPERTY COMPILE_DEFINITIONS
-  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT)
+  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT=)
 swig_add_library(pywrapknapsack_solver
   TYPE MODULE
   LANGUAGE python
diff --git a/ortools/constraint_solver/python/CMakeLists.txt b/ortools/constraint_solver/python/CMakeLists.txt
index 70c924433f..4606db3d41 100644
--- a/ortools/constraint_solver/python/CMakeLists.txt
+++ b/ortools/constraint_solver/python/CMakeLists.txt
@@ -14,7 +14,7 @@
 set_property(SOURCE routing.i PROPERTY CPLUSPLUS ON)
 set_property(SOURCE routing.i PROPERTY SWIG_MODULE_NAME pywrapcp)
 set_property(SOURCE routing.i PROPERTY COMPILE_DEFINITIONS
-  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT)
+  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT=)
 set_property(SOURCE routing.i PROPERTY COMPILE_OPTIONS -nofastunpack)
 swig_add_library(pywrapcp
   TYPE MODULE
diff --git a/ortools/init/python/CMakeLists.txt b/ortools/init/python/CMakeLists.txt
index 6f16231159..4669ca0885 100644
--- a/ortools/init/python/CMakeLists.txt
+++ b/ortools/init/python/CMakeLists.txt
@@ -14,7 +14,7 @@
 set_property(SOURCE init.i PROPERTY CPLUSPLUS ON)
 set_property(SOURCE init.i PROPERTY SWIG_MODULE_NAME pywrapinit)
 set_property(SOURCE init.i PROPERTY COMPILE_DEFINITIONS
-  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT)
+  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT=)
 swig_add_library(pywrapinit
   TYPE MODULE
   LANGUAGE python
diff --git a/ortools/linear_solver/python/CMakeLists.txt b/ortools/linear_solver/python/CMakeLists.txt
index d8eda86af6..ac25c9bddd 100644
--- a/ortools/linear_solver/python/CMakeLists.txt
+++ b/ortools/linear_solver/python/CMakeLists.txt
@@ -14,7 +14,7 @@
 set_property(SOURCE linear_solver.i PROPERTY CPLUSPLUS ON)
 set_property(SOURCE linear_solver.i PROPERTY SWIG_MODULE_NAME pywraplp)
 set_property(SOURCE linear_solver.i PROPERTY COMPILE_DEFINITIONS
-  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT)
+  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT=)
 swig_add_library(pywraplp
   TYPE MODULE
   LANGUAGE python
diff --git a/ortools/scheduling/python/CMakeLists.txt b/ortools/scheduling/python/CMakeLists.txt
index 482f343982..5350807948 100644
--- a/ortools/scheduling/python/CMakeLists.txt
+++ b/ortools/scheduling/python/CMakeLists.txt
@@ -14,7 +14,7 @@
 set_property(SOURCE rcpsp.i PROPERTY CPLUSPLUS ON)
 set_property(SOURCE rcpsp.i PROPERTY SWIG_MODULE_NAME pywraprcpsp)
 set_property(SOURCE rcpsp.i PROPERTY COMPILE_DEFINITIONS
-  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT)
+  ${OR_TOOLS_COMPILE_DEFINITIONS} ABSL_MUST_USE_RESULT=)
 swig_add_library(pywraprcpsp
   TYPE MODULE
   LANGUAGE python